|
T1760 |
TBPB
|
|
AChR
|
|
TBPB is an allosteric M1 mAChR agonist. |
|
T11078 |
Deschloroclozapine
|
|
Serotonin Transporter
|
|
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. |
|
T7555 |
Piperidolate hydrochloride
|
|
AChR
|
|
Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs). |
|
T23116 |
Oxotremorine sesquifumarate
|
|
AChR
|
|
Oxotremorine sesquifumarate is a muscarinic agonist. |
|
T4981 |
Anisotropine Methylbromide
|
|
Prostaglandin Receptor
,
AChR
|
|
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion. |
|
T1281 |
Tropicamide
|
Ro 1-7683 |
AChR
|
|
Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ... |
|
T11095L |
DREADD agonist 21
|
|
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
|
|
DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM). |
|
T6575 |
LY2119620
|
|
AChR
|
|
LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. |
|
T9419 |
Fesoterodine
|
(R) Fesoterodine |
AChR
|
|
Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB). |
|
T6548 |
Irsogladine
|
Dicloguamine |
PDE
,
AChR
|
|
Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. |
|
T29123 |
VU0152099
|
VU 0152099,VU-0152099 |
AChR
|
|
VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM). |
|
T8219 |
VU0238441
|
|
AChR
|
|
VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM. |
|
T13066 |
TAK-071
|
|
AChR
|
|
TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM). |
|
T17244 |
VU0467154
|
|
AChR
|
|
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, and cynomolgus monkey M4 receptor, respectively. |
|
T7405 |
Piperidolate
|
|
AChR
|
|
Piperidolate inhibits intestinal cramp induced by acetylcholine |
|
T13325 |
VU 0365114
|
|
AChR
|
|
VU 0365114 is a positive allosteric modulator of mAChR M5 (EC50: 2.7 μM). |
|
T5655 |
MAChR-IN-1 hydrochloride
|
|
AChR
|
|
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm. |
|
T9420 |
Prifinium bromide
|
|
Others
|
|
Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action. |
|
T3993 |
BQCA
|
benzylquinolone carboxylic acid |
AChR
|
|
BQCA (benzylquinolone carboxylic acid) a highly selective allosteric M1 mAChR modulator. |
|
T4997 |
Umeclidinium bromide
|
GSK573719A |
AChR
|
|
Umeclidinium bromide (GSK573719A) is a novel mAChR antagonist. |
|
T23513 |
VU10010
|
VU 10010 |
AChR
|
|
VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors. |
|
T15942 |
MK-7622
|
M1 receptor modulator |
AChR
|
|
MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric. |
|
T8224 |
VU0119498
|
|
AChR
|
|
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent. |
|
T9694 |
Emraclidine
|
CVL-231 |
AChR
|
|
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator and can be used in neurological diseases studies. |
|
T23524 |
W-84 dibromide
|
HDMPPA |
AChR
|
|
W-84 dibromide (HDMPPA) is a M2-receptor selective modulator. |
|
T8383 |
Cyclopentolate Hydrochloride
|
|
AChR
|
|
Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively. |
|
T1460 |
Dicyclomine hydrochloride
|
|
AChR
|
|
Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence. |
|
T4979 |
Procyclidine hydrochloride
|
(±)-Procyclidine hydrochlorid |
NMDAR
,
iGluR
|
|
Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties. |
|
T8007 |
VU 0238429
|
SCR-1481B1,VU0238429 |
AChR
|
|
VU 0238429 (SCR-1481B1) is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM). |
|
T23508 |
VU 0255035
|
|
AChR
|
|
muscarinic M1 antagonist |
|
T0427 |
Homatropine Methylbromide
|
Homatropine methobromide |
AChR
|
|
Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. |
|
T2390 |
Cevimeline hydrochloride hemihydrate
|
|
AChR
|
|
Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome. |
|
T9019 |
JHU37152
|
JHU 37152 |
AChR
|
|
JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ... |
|
T28827 |
Sofpironium bromide
|
BBI4000,BBI 4000,BBI-4000 |
Others
,
AChR
|
|
Sofpironium bromide (BBI4000) belongs to a class of drugs called anticholinergics, which exert their effect by blocking the action of acetylcholine. |
|
T1475 |
Fesoterodine fumarate
|
Toviaz,SPM 907 |
AChR
|
|
Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo... |
|
T9018 |
JHU37160
|
JHU 37160 |
AChR
|
|
JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ... |
|
T16411 |
Otenzepad
|
AF-DX 116 |
AChR
|
|
Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung. |
|
T1179 |
Tiotropium bromide
|
Tiopropium,BA679 BR |
AChR
|
|
Tiotropium bromide (BA679 BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical a... |
|
T28069 |
ML380
|
ML 380,ML-380 |
AChR
|
|
ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM). |
|
T0720 |
Gallamine triethiodide
|
Benzkurin,Flaxedil |
AChR
|
|
Gallamine triethiodide (Benzkurin), a synthetic inhibiting drug, is nondepolarizing. |
|
T4494 |
CLOZAPINE N-OXIDE
|
|
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Drug Metabolite
|
|
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopa... |
|
T22380 |
Nor-benzetimide
|
|
Others
,
AChR
|
|
Norbenzetimide, an organic compound, is prepared from benzetimide by catalytic transfer hydrogenolysis. |
|
T29137 |
VU0453595
|
VU 0453595,VU-0453595 |
AChR
|
|
VU0453595 is a M1 positive allosteric modulator (PAM). |
|
T14345 |
Atropine methyl bromide
|
Methylatropine bromide |
AChR
|
|
Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist. It functions as a mydriatic to dilate the pupil during ophthalmic exa... |
|
T5023 |
Propiverine hydrochloride
|
|
Others
,
Calcium Channel
,
AChR
|
|
Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB). |
|
T7079 |
Batefenterol
|
GSK961081,TD-5959 |
Adrenergic Receptor
,
AChR
|
|
Batefenterol (TD-5959) (GSK961081, TD-5959) is a muscarinic receptor antagonist and β2-adrenoceptor agonist. It displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor (Ki:1.4/1.3/3.7 nM). |
|
T17238 |
VU0152100
|
VU152100 |
AChR
|
|
VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM). |
|
T0099 |
Tolterodine tartrate
|
Detrol LA,PNU-200583E,Kabi-2234 |
AChR
|
|
Tolterodine tartrate (PNU-200583E) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo. |
|
T3619 |
VU0357017 hydrochloride
|
ML071 hydrochloride,CID-25010775,VU 0357017 hydrochloride |
AChR
|
|
VU0357017 hydrochloride (ML071 hydrochloride) is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15). |
|
T5158 |
N-Desmethylclozapine
|
Desmethylclozapine,Normethylclozapine,Norclozapine |
Virus Protease
,
Dopamine Receptor
,
5-HT Receptor
,
Opioid Receptor
,
AChR
,
Drug Metabolite
|
|
N-Desmethylclozapine (Desmethylclozapine) is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors. |
